Disruption of a Salt Bridge Dramatically Accelerates Subunit Exchange in Duck δ2 Crystallin
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چکیده
منابع مشابه
Mutations in Human αA-Crystallin/sHSP Affect Subunit Exchange Interaction with αB-Crystallin
BACKGROUND Mutation in αA-crystallin contributes to the development of congenital cataract in humans. Heterooligomerization of αA-crystallin and αB-crystallin is essential for maintaining transparency in the eye lens. The effect of congenital cataract causing mutants of αA-crystallin on subunit exchange and interaction with αB-crystallin is unknown. In the present study, interaction of the muta...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m405300200